• 靶点：
• SDS3

• 基因名称：
• SUDS3 SAP45 SDS3

• 蛋白名称：
• SDS3

• Human Gene Id：
• 64426

• Human Swiss Prot No：
• Q9H7L9

• Mouse Gene Id：
• 71954

• Mouse Swiss Prot No：
• Q8BR65

• 免疫原：
• Synthesized peptide derived from human SDS3 AA range: 96-146

• 特异性：
• This antibody detects endogenous levels of SDS3 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 36kD

• 背景：
• SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008],

• 功能：
• domain:The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.,function:Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways (By similarity). May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.,similarity:Belongs to the SDS3 family.,subunit:Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity). Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2.,tissue specificity:Expressed in various cancer cell ines.

• 细胞定位：
• Nucleus .

• 组织表达：
• Expressed in various cancer cell ines.

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