• 靶点：
• SRGP2

• 简介：
• >>Axon guidance

• 基因名称：
• SRGAP2 ARHGAP34 FNBP2 KIAA0456 SRGAP2A

• 蛋白名称：
• SRGP2

• Human Gene Id：
• 23380

• Human Swiss Prot No：
• O75044

• Mouse Gene Id：
• 14270

• Mouse Swiss Prot No：
• Q91Z67

• Rat Swiss Prot No：
• D4A208

• 免疫原：
• Synthesized peptide derived from human SRGP2 AA range: 476-526

• 特异性：
• This antibody detects endogenous levels of SRGP2 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 118kD

• 背景：
• This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014],

• 功能：
• function:Putative GTPase-activating protein for Rho family small GTPases.,similarity:Contains 1 FCH domain.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,subunit:Probably interacts with ROBO1.,tissue specificity:Expression at low levels in placenta, kidney, and ovary, and little or no expression in all other tissues tested.,

• 细胞定位：
• Cell membrane . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic density . Cell junction, synapse, postsynaptic cell membrane . Cell projection, lamellipodium . Cytoplasmic vesicle, phagosome . Nucleus . Cytoplasm, cytosol . Recruited to actin-rich phagosomes during phagocytosis (By similarity). Translocates from nucleus to cytoplasm during development (By similarity). .

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