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NMNA3 rabbit pAb

货号：YT6812
应用：WB
种属：Human;Mouse

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靶点：
NMNA3

简介：
>>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors

基因名称：
NMNAT3 FKSG76

蛋白名称：
NMNA3

Human Gene Id：
349565

Human Swiss Prot No：
Q96T66

Mouse Gene Id：
74080

Mouse Swiss Prot No：
Q99JR6

免疫原：
Synthesized peptide derived from human NMNA3 AA range: 97-147

特异性：
This antibody detects endogenous levels of NMNA3 at Human/Mouse

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1：500-2000

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

分子量：
28kD

背景：
This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],

功能：
catalytic activity:ATP + nicotinamide ribonucleotide = diphosphate + NAD(+).,catalytic activity:ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD(+).,cofactor:Divalent metal cations. Magnesium confers the highest activity.,enzyme regulation:Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate (Nap4AD).,function:Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotina

细胞定位：
Mitochondrion .

组织表达：
Expressed in lung and spleen with lower levels in placenta and kidney.

NMNATs expression inhibition mediated NAD+ deficiency plays a critical role in doxorubicin-induced hepatotoxicity in mice TOXICOLOGY AND APPLIED PHARMACOLOGY Fang Cheng WB Mouse 1:1000 liver tissue
货号：YT6812