• 靶点：
• CMPK2

• 简介：
• >>Pyrimidine metabolism;>>Metabolic pathways;>>Nucleotide metabolism;>>Biosynthesis of cofactors

• 基因名称：
• CMPK2

• 蛋白名称：
• CMPK2

• Human Gene Id：
• 129607

• Human Swiss Prot No：
• Q5EBM0

• Mouse Gene Id：
• 22169

• Mouse Swiss Prot No：
• Q3U5Q7

• 免疫原：
• Synthesized peptide derived from human CMPK2 AA range: 57-107

• 特异性：
• This antibody detects endogenous levels of CMPK2 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 49kD

• 背景：
• This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012],

• 功能：
• catalytic activity:ATP + (d)CMP = ADP + (d)CDP.,function:May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs.,similarity:Belongs to the thymidylate kinase family.,tissue specificity:Among all investigated tumors, leukemia cells show the most abundant expression.,

• 细胞定位：
• Mitochondrion .

• 组织表达：
• Among all investigated tumors, leukemia cells show the most abundant expression.

Cmpk2 regulates mitochondrial function in glucocorticoid-induced osteoblast senescence and affects glucocorticoid-inhibited osteoblast differentiation. Ye Tian WB Mouse 1:1000 Bone marrow mesenchymal stem cells (BMSCs),MC3T3-E1 cell
货号：YT6811

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