• 靶点：
• SMS1

• 简介：
• >>Sphingolipid metabolism;>>Metabolic pathways;>>Sphingolipid signaling pathway

• 基因名称：
• SGMS1 MOB SMS1 TMEM23

• 蛋白名称：
• SMS1

• Human Gene Id：
• 259230

• Human Swiss Prot No：
• Q86VZ5

• Mouse Gene Id：
• 208449

• Mouse Swiss Prot No：
• Q8VCQ6

• Rat Gene Id：
• 353229

• Rat Swiss Prot No：
• Q7TSX5

• 免疫原：
• Synthesized peptide derived from human SMS1 AA range: 156-206

• 特异性：
• This antibody detects endogenous levels of SMS1 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 46kD

• 背景：
• The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol.,enzyme regulation:Inhibited by bacterial PC-phospholipase C inhibitor D609.,function:Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect a

• 细胞定位：
• Golgi apparatus membrane ; Multi-pass membrane protein .

• 组织表达：
• Brain, heart, kidney, liver, muscle and stomach.

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