• 靶点：
• MTDC

• 简介：
• >>One carbon pool by folate;>>Metabolic pathways;>>Biosynthesis of cofactors

• 基因名称：
• MTHFD2 NMDMC

• 蛋白名称：
• MTDC

• Human Gene Id：
• 10797

• Human Swiss Prot No：
• P13995

• Mouse Gene Id：
• 17768

• Mouse Swiss Prot No：
• P18155

• 免疫原：
• Synthesized peptide derived from human MTDC AA range: 121-171

• 特异性：
• This antibody detects endogenous levels of MTDC at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 39kD

• 背景：
• This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009],

• 功能：
• catalytic activity:5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.,catalytic activity:5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.,cofactor:Magnesium.,developmental stage:Expressed only in developing normal tissues.,miscellaneous:This NAD-dependent bifunctional enzyme has very different kinetic properties than the larger NADP-dependent trifunctional enzyme and is unique in that it requires formation of an enzyme-magnesium complex to allow binding of NAD.,similarity:Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.,subunit:Homodimer.,

• 细胞定位：
• Mitochondrion.

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