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WB 试剂
- PonceauS Staining Solution
- PBST Washing Buffer, 10X
- 1.5M Tris-HCl Buffer, pH8.8
- 1M Tris-HCl Buffer, pH6.8
- 10% SDS Solution
- Prestained Protein Marker
- TBST Washing Buffer, 10X
- SDS PAGE Loading Buffer, 5X
- Stripping Buffered Solution
- Tris Buffer, pH7.4, 10X
- Total Protein Extraction Kit
- Running Buffer, 10X
- Transfer Buffer, 10X
- 30% Acr-Bis(29:1) Solution
- Tris电泳液速溶颗粒
- PBS(1X, premixed powder)
- TBS(1X, premixed powder)
- 快速封闭液
- 转膜液速溶颗粒
- Chemical reagents
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TWF1 rabbit pAb
- 货号:YT6671
- 应用:WB
- 种属:Human;Mouse;Rat
- 免疫原:
- Synthesized peptide derived from human TWF1 AA range: 179-229
- 特异性:
- This antibody detects endogenous levels of TWF1 at Human/Mouse/Rat
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 背景:
- This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008],
- 功能:
- caution:Was originally (PubMed:7507208) thought to have protein tyrosine kinase activity.,function:Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.,online information:Molecular embrace -Issue 73 of August 2006,PTM:Phosphorylated on serine and threonine residues.,similarity:Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.,similarity:Contains 2 ADF-H domains.,subcellular location:Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts.,subunit:Interacts with G-actin; ADP-actin form and capping protein (CP).
- 细胞定位:
- Cytoplasm. Cytoplasm, cytoskeleton . Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). .
- 组织表达:
- Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.
![](/uploadfiles/PIC/YT6671wb-2019.jpg)
- Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night