• 靶点：
• AP2B1

• 简介：
• >>Endocytosis;>>Synaptic vesicle cycle;>>Endocrine and other factor-regulated calcium reabsorption;>>Huntington disease

• 基因名称：
• AP2B1 ADTB2 CLAPB1

• 蛋白名称：
• AP2B1

• Human Gene Id：
• 163

• Human Swiss Prot No：
• P63010

• Mouse Gene Id：
• 71770

• Mouse Swiss Prot No：
• Q9DBG3

• Rat Gene Id：
• 100912146

• Rat Swiss Prot No：
• P62944

• 免疫原：
• Synthesized peptide derived from human AP2B1 AA range: 70-120

• 特异性：
• This antibody detects endogenous levels of AP2B1 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 103kD

• 背景：
• The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• function:Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP2B1 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositides.,similarity:Belongs to the adaptor complexes large subunit family.,subcellular location:Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.,subunit:Adaptor protein complex 2 (AP-2) is an heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Binds EPN1, EPS15, SNAP91 and clathrin.,

• 细胞定位：
• Cell membrane . Membrane, coated pit ; Peripheral membrane protein ; Cytoplasmic side . AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.

• 组织表达：
• Expressed in the brain (at protein level).

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