• 靶点：
• LKHA4

• 简介：
• >>Arachidonic acid metabolism;>>Metabolic pathways

• 基因名称：
• LTA4H LTA4

• 蛋白名称：
• LKHA4

• Human Gene Id：
• 4048

• Human Swiss Prot No：
• P09960

• Mouse Gene Id：
• 16993

• Mouse Swiss Prot No：
• P24527

• Rat Swiss Prot No：
• P30349

• 免疫原：
• Synthesized peptide derived from human LKHA4 AA range: 68-118

• 特异性：
• This antibody detects endogenous levels of LKHA4 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 67kD

• 背景：
• The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015],

• 功能：
• catalytic activity:(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.,cofactor:Binds 1 zinc ion per subunit.,function:Hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). The enzyme also has some peptidase activity.,pathway:Lipid metabolism; leukotriene B4 biosynthesis.,similarity:Belongs to the peptidase M1 family.,subunit:Monomer.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.

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