• 靶点：
• SO1C1

• 简介：
• >>Thyroid hormone signaling pathway

• 基因名称：
• SLCO1C1 OATP14 OATP1C1 OATPF SLC21A14

• 蛋白名称：
• SO1C1

• Human Gene Id：
• 53919

• Human Swiss Prot No：
• Q9NYB5

• Mouse Gene Id：
• 58807

• Mouse Swiss Prot No：
• Q9ERB5

• Rat Gene Id：
• 84511

• Rat Swiss Prot No：
• Q9EPZ7

• 免疫原：
• Synthesized peptide derived from human SO1C1 AA range: 634-684

• 特异性：
• This antibody detects endogenous levels of SO1C1 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 78kD

• 背景：
• This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009],

• 功能：
• function:Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency.,similarity:Belongs to the organo anion transporter (TC 2.A.60) family.,tissue specificity:Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein . Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity). .

• 组织表达：
• Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.

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