• 靶点：
• UBE2B

• 简介：
• >>Ubiquitin mediated proteolysis

• 基因名称：
• UBE2B RAD6B

• 蛋白名称：
• UBE2B

• Human Gene Id：
• 7320

• Human Swiss Prot No：
• P63146

• Mouse Gene Id：
• 22210

• Mouse Swiss Prot No：
• P63147

• Rat Gene Id：
• 81816

• Rat Swiss Prot No：
• P63149

• 免疫原：
• Synthesized peptide derived from human UBE2B AA range: 23-73

• 特异性：
• This antibody detects endogenous levels of UBE2B at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 17kD

• 背景：
• The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subcellular location:In peripheral neurons, expressed both at the plasma membrane and in nuclei.,subunit:Interacts with RAD18 and UBR2.,

• 细胞定位：
• Cell membrane . Nucleus . In peripheral neurons, expressed both at the plasma membrane and in nuclei. .

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