APOC1 Polyclonal Antibody
- 货号:YT6255
- 应用:IHC;ELISA
- 种属:Human;Rat;Mouse;
- 简介:
- >>Cholesterol metabolism
- 免疫原:
- Synthesized peptide derived from human APOC1 AA range: 1-50
- 特异性:
- This antibody detects endogenous levels of human APOC1
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- IHC 1:50-200, ELISA(peptide)1:5000-20000
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- Apolipoprotein C-I (Apo-CIB;ApoC-IB;Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I (Apo-CIB';ApoC-IB')]
- 背景:
- This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016],
- 功能:
- function:Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein.,miscellaneous:Apo-CI makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high density lipoprotein).,online information:Apolipoprotein C1 entry,similarity:Belongs to the apolipoprotein C1 family.,tissue specificity:Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma.,
- 组织表达:
- Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen.
![](/uploadfiles/PIC/153biantaoticc.jpg)
- Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).