• 靶点：
• Granzyme B

• 简介：
• >>Apoptosis;>>Natural killer cell mediated cytotoxicity;>>Type I diabetes mellitus;>>Transcriptional misregulation in cancer;>>Autoimmune thyroid disease;>>Allograft rejection;>>Graft-versus-host disease

• 基因名称：
• GZMB CGL1 CSPB CTLA1 GRB

• 蛋白名称：
• Granzyme B (EC 3.4.21.79) (C11) (CTLA-1) (Cathepsin G-like 1) (CTSGL1) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (Fragmentin-2) (Granzyme-2) (Human lymphocyte protein) (HLP) (SECT) (

• Human Gene Id：
• 3002

• Human Swiss Prot No：
• P10144

• Mouse Gene Id：
• 14939

• Mouse Swiss Prot No：
• P04187

• Rat Gene Id：
• 100361468

• Rat Swiss Prot No：
• P18291

• 免疫原：
• Synthesized peptide derived from human Granzyme B Polyclonal AA range: 81-130

• 特异性：
• This antibody detects endogenous levels of Granzyme B.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC: 100-300.WB 1:500-2000, ELISA 1:10000-20000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Granzyme B (EC 3.4.21.79;C11;CTLA-1;Cathepsin G-like 1;CTSGL1;Cytotoxic T-lymphocyte proteinase 2;Lymphocyte protease;Fragmentin-2;Granzyme-2;Human lymphocyte protein;HLP;SECT;T-cell serine protease 1-3E)

• 实测条带：
• 38kD

• 背景：
• This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016],

• 功能：
• catalytic activity:Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa-.,function:This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.,induction:By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subcellular location:Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.,

• 细胞定位：
• Secreted . Cytolytic granule . Delivered into the target cell by perforin (PubMed:20038786). .

• 组织表达：
• Breast carcinoma,Large granular lymphocyte leukemia,Pancreas,

Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC. Journal of Immunology Research J Immunol Res. 2021;2021:6694392 IHC Mouse KPC1199-luc cell-Xenograft
货号：YT6137

Synergistic Anti-Tumor Efficacy Achieved by Reversing Drug Resistance through the Regulation of the Tumor Immune Microenvironment with IL-12 and Osimertinib Combination Therapy Journal of Cancer Ding Huiqin WB Mouse H1975 cell-Xenograft
货号：YT6137

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