• 靶点：
• C1RL

• 基因名称：
• C1RL

• 蛋白名称：
• C1RL

• Human Gene Id：
• 51279

• Human Swiss Prot No：
• Q9NZP8

• Mouse Gene Id：
• 232371

• Mouse Swiss Prot No：
• Q3UZ09

• 免疫原：
• Synthesized peptide derived from human C1RL. at AA range: 371-420

• 特异性：
• C1RL Polyclonal Antibody detects endogenous levels of C1RL

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000, ELISA 1:10000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Complement C1r subcomponent-like protein (C1r-LP) (C1r-like protein) (EC 3.4.21.-) (C1r-like serine protease analog protein) (CLSPa)

• 实测条带：
• 53kD

• 背景：
• caution:Does not associate with the C1 complex. According to PubMed:15385675 doesn't cleave the proform of complement C1s.,function:Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.,induction:Up-regulated in monocytes and dendritic cells (DC) undergoing maturation or activation.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 CUB domain.,similarity:Contains 1 peptidase S1 domain.,tissue specificity:Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U251 (glioma) or A549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level).,

• 功能：
• caution:Does not associate with the C1 complex. According to PubMed:15385675 doesn't cleave the proform of complement C1s.,function:Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.,induction:Up-regulated in monocytes and dendritic cells (DC) undergoing maturation or activation.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 CUB domain.,similarity:Contains 1 peptidase S1 domain.,tissue specificity:Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast

• 细胞定位：
• Secreted .

• 组织表达：
• Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level).

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