• 靶点：
• ACO2

• 简介：
• >>Citrate cycle (TCA cycle);>>Glyoxylate and dicarboxylate metabolism;>>Metabolic pathways;>>Carbon metabolism;>>2-Oxocarboxylic acid metabolism;>>Biosynthesis of amino acids

• 基因名称：
• ACO2

• 蛋白名称：
• ACO2

• Human Gene Id：
• 50

• Human Swiss Prot No：
• Q99798

• Mouse Gene Id：
• 11429

• Mouse Swiss Prot No：
• Q99KI0

• 免疫原：
• Synthesized peptide derived from human ACO2. at AA range: 421-470

• 特异性：
• ACO2 Polyclonal Antibody detects endogenous levels of ACO2

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:5000.Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)

• 实测条带：
• 90kD

• 背景：
• The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:Citrate = isocitrate.,cofactor:Binds 1 4Fe-4S cluster per subunit. Binding of a 3Fe-4S cluster leads to an inactive enzyme.,online information:Aconitase entry,pathway:Carbohydrate metabolism; tricarboxylic acid cycle.,similarity:Belongs to the aconitase/IPM isomerase family.,subunit:Monomer.,

• 细胞定位：
• Mitochondrion .

• 组织表达：
• Brain,Cajal-Retzius cell,Fetal brain cortex,Skeletal muscle,Uterus,

Epigallocatechin‐3‐gallate activates the AMP‐activated protein kinase signaling pathway to reduce lipid accumulation in canine hepatocytes. JOURNAL OF CELLULAR PHYSIOLOGY J Cell Physiol. 2021 Jan;236(1):405-416 WB Canine 1:500 Hepatocytes
货号：YT6104

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