Granzyme M Polyclonal Antibody
- 货号：YT6049
- 应用：IHC;IF;ELISA
- 种属：Human;Rat
- 蛋白名称：
- Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease)
- 免疫原：
- Synthetic peptide from human protein at AA range: 207-256
- 特异性：
- The antibody detects endogenous Granzyme M
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Granzyme M (EC 3.4.21.-;Met-1 serine protease;Hu-Met-1;Met-ase;Natural killer cell granular protease)
- 背景：
- Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],
- 功能：
- function:Cleaves peptide substrates after methionine, leucine, and norleucine.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subcellular location:Granules of large granular lymphocytes.,
- 细胞定位：
- Secreted. Cytoplasmic granule. Granules of large granular lymphocytes.
- 组织表达：
- Highly and constitutively expressed in activated natural killer (NK) cells.
- Immunohistochemical analysis of paraffin-embedded Human-lymph, antibody was diluted at 1:100
- Immunohistochemical analysis of paraffin-embedded Human-lymph, antibody was diluted at 1:100
