Epiregulin Polyclonal Antibody
- 货号：YT6045
- 应用：IHC;IF;ELISA
- 种属：Human;Mouse;Rat
- 简介：
- >>MAPK signaling pathway;>>ErbB signaling pathway;>>PI3K-Akt signaling pathway;>>Colorectal cancer
- 蛋白名称：
- Proepiregulin [Cleaved into: Epiregulin (EPR)]
- 免疫原：
- Synthetic peptide from human protein at AA range: 71-120
- 特异性：
- The antibody detects endogenous Epiregulin
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Proepiregulin [Cleaved into: Epiregulin (EPR)]
- 背景：
- This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015],
- 功能：
- function:May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis.,similarity:Contains 1 EGF-like domain.,tissue specificity:In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.,
- 细胞定位：
- [Epiregulin]: Secreted, extracellular space .; [Proepiregulin]: Cell membrane ; Single-pass type I membrane protein .
- 组织表达：
- In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.
- Immunohistochemical analysis of paraffin-embedded Human-liver, antibody was diluted at 1:100
