- 靶点:
- IL-8RA
- 简介:
- >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>Phospholipase D signaling pathway;>>Endocytosis;>>Epithelial cell signaling in Helicobacter pylori infection
- 基因名称:
- CXCR1 CMKAR1 IL8RA
- 蛋白名称:
- C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)
- Human Gene Id:
- 3577
- Human Swiss Prot No:
- P25024
- Mouse Gene Id:
- 227288
- Mouse Swiss Prot No:
- Q810W6
- 免疫原:
- Synthetic peptide from human protein at AA range: 1-50
- 特异性:
- The antibody detects endogenous IL-8RA
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500-2000 IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度:
- 1 mg/ml
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- C-X-C chemokine receptor type 1 (CXC-R1;CXCR-1;CDw128a;High affinity interleukin-8 receptor A;IL-8R A;IL-8 receptor type 1;CD antigen CD181)
- 分子量:
- 40kD
- 背景:
- C-X-C motif chemokine receptor 1(CXCR1) Homo sapiens The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008],
- 功能:
- function:Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.,online information:CXC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
- 细胞定位:
- Cell membrane; Multi-pass membrane protein.
- 组织表达:
- Blood,Placenta,
CSF2 upregulates CXCL3 expression in adipocytes to promote metastasis of breast cancer via the FAK signaling pathway Journal of Molecular Cell Biology Xiangyang Xiong WB Human MCF10A cell,MDA-MB-231 cell,BT549 cell,MCF-7 cell,T47D cell
货号:YT6039
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- Antibody-FAQs
- 产品图片
- Immunohistochemical analysis of paraffin-embedded Human-liver-cancer, antibody was diluted at 1:100
- Immunohistochemical analysis of paraffin-embedded Human-placenta, antibody was diluted at 1:100