• 靶点：
• CD42c

• 简介：
• >>ECM-receptor interaction;>>Platelet activation;>>Hematopoietic cell lineage

• 基因名称：
• GP1BB

• 蛋白名称：
• Platelet glycoprotein Ib beta chain (GP-Ib beta) (GPIb-beta) (GPIbB) (Antigen CD42b-beta) (CD antigen CD42c)

• Human Gene Id：
• 2812

• Human Swiss Prot No：
• P13224

• Mouse Gene Id：
• 14724

• Mouse Swiss Prot No：
• P56400

• 免疫原：
• Synthetic peptide from human protein at AA range: 90-150

• 特异性：
• The antibody detects endogenous CD42c

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Platelet glycoprotein Ib beta chain (GP-Ib beta;GPIb-beta;GPIbB;Antigen CD42b-beta;CD antigen CD42c)

• 背景：
• Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, t

• 功能：
• disease:Defects in GP1BB are a cause of Bernard-Soulier syndrome (BSS) [MIM:231200]; also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency.,function:Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.,miscellaneous:Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.,similarity:Contains 1 LRR (leucine-rich) repeat.,subunit:GP-Ib alpha and beta are disulfide linked. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage.,tissue specificity:Expressed in heart and brain.,

• 细胞定位：
• Membrane; Single-pass type I membrane protein.

• 组织表达：
• Expressed in heart and brain.

Naoxintong capsule limits myocardial infarct expansion by inhibiting platelet activation through the ERK5 pathway Phytomedicine. 2022 Apr;98:153953. IHC Rat Cardiac
货号：YT6028

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