ASPP1 Polyclonal Antibody
- 货号：YT6010
- 应用：IHC;IF;ELISA
- 种属：Human;Mouse
- 基因名称：
- PPP1R13B ASPP1 KIAA0771
- 蛋白名称：
- Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B)
- 免疫原：
- Synthetic peptide from human protein at AA range: 630-680
- 特异性：
- The antibody detects endogenous ASPP1
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B)
- 背景：
- This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008],
- 功能：
- disease:Defects in PPP1R13B may be a cause of breast cancers. It is overexpressed in many patients suffering from breast carcinomas and expressing a wild-type TP53 protein.,domain:The ankyrin repeats and the SH3 domain are required for specific interactions with TP53.,function:Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.,miscellaneous:In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1.,similarity:Belongs to the ASPP family.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 ANK repeats.,subcellular location:Predominantly cytoplasmic. Some fraction is nuclear.,subunit:I
- 细胞定位：
- Cytoplasm . Nucleus . Predominantly cytoplasmic. Some fraction is nuclear.
- 组织表达：
- Reduced expression in breast carcinomas expressing a wild-type TP53 protein.
- Immunohistochemical analysis of paraffin-embedded Human-liver, antibody was diluted at 1:100
