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GSTA1 Polyclonal Antibody

货号：YT5981
应用：WB;IP;IHC;IF;ELISA
种属：Human;Rat;Mouse;

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靶点：
GSTA1

简介：
>>Glutathione metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Drug metabolism - cytochrome P450;>>Drug metabolism - other enzymes;>>Metabolic pathways;>>Platinum drug resistance;>>Pathways in cancer;>>Chemical carcinogenesis - DNA adducts;>>Chemical carcinogenesis - receptor activation;>>Chemical carcinogenesis - reactive oxygen species;>>Hepatocellular carcinoma;>>Fluid shear stress and atherosclerosis

基因名称：
GSTA1

蛋白名称：
Glutathione S-transferase A1 (EC 2.5.1.18) (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1)

Human Gene Id：
2938

Human Swiss Prot No：
P08263

Mouse Gene Id：
14857

Mouse Swiss Prot No：
P13745

免疫原：
The antiserum was produced against synthesized peptide derived from the Internal region of human GSTA1. AA range:91-140

特异性：
The antibody detects endogenous GSTA1

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500-2000 IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
Glutathione S-transferase A1 (EC 2.5.1.18;GST HA subunit 1;GST class-alpha member 1;GST-epsilon;GSTA1-1;GTH1)

分子量：
26kD

背景：
This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],

功能：
catalytic activity:RX + glutathione = HX + R-S-glutathione.,domain:The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity.,function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.,similarity:Belongs to the GST superfamily.,similarity:Belongs to the GST superfamily. Alpha family.,similarity:Contains 1 GST C-terminal domain.,similarity:Contains 1 GST N-terminal domain.,subunit:Homodimer or heterodimer of GSTA1 and GSTA2.,tissue specificity:Liver.,

细胞定位：
Cytoplasm.

组织表达：
Liver.

Cellular 5′-3′ mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication | mBio. mBio Mbio. 2021 Aug;: Pull Down，WB,IP Human 1:1000 HEK293T cells
货号：YT5981