• 靶点：
• CD231

• 简介：
• >>Transcriptional misregulation in cancer

• 基因名称：
• TSPAN7 A15 DXS1692E MXS1 TM4SF2

• 蛋白名称：
• Tetraspanin-7 (Tspan-7) (Cell surface glycoprotein A15) (Membrane component chromosome X surface marker 1) (T-cell acute lymphoblastic leukemia-associated antigen 1) (TALLA-1) (Transmembrane 4 superfa

• Human Gene Id：
• 7102

• Human Swiss Prot No：
• P41732

• Mouse Gene Id：
• 21912

• Mouse Swiss Prot No：
• Q62283

• 免疫原：
• Synthetic peptide from human protein at AA range: 101-150

• 特异性：
• The antibody detects endogenous CD231

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Tetraspanin-7 (Tspan-7;Cell surface glycoprotein A15;Membrane component chromosome X surface marker 1;T-cell acute lymphoblastic leukemia-associated antigen 1;TALLA-1;Transmembrane 4 superfamily member 2;CD antigen CD231)

• 背景：
• The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in TSPAN7 are the cause of mental retardation X-linked type 58 (MRX58) [MIM:300210]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.,function:May be involved in cell proliferation and cell motility.,similarity:Belongs to the tetraspanin (TM4SF) family.,tissue specificity:Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.,

• 细胞定位：
• Membrane; Multi-pass membrane protein.

• 组织表达：
• Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.

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