ImmunoWay Biotechnology Company |抗体|病理抗体|诊断抗体

CKR-1 Polyclonal Antibody

货号：YT5941
应用：IHC;IF;ELISA
种属：Human;Mouse

产品详情
文献 ( 1 )
操作手册

靶点：
CKR-1

简介：
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>Human cytomegalovirus infection;>>Kaposi sarcoma-associated herpesvirus infection

基因名称：
CCR1 CMKBR1 CMKR1 SCYAR1

蛋白名称：
C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)

Human Gene Id：
1230

Human Swiss Prot No：
P32246

Mouse Gene Id：
12768

Mouse Swiss Prot No：
P51675

免疫原：
Synthetic peptide from human protein at AA range: 151-200

特异性：
The antibody detects endogenous CKR-1

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
C-C chemokine receptor type 1 (C-C CKR-1;CC-CKR-1;CCR-1;CCR1;HM145;LD78 receptor;Macrophage inflammatory protein 1-alpha receptor;MIP-1alpha-R;RANTES-R;CD antigen CD191)

背景：
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

功能：
function:Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.,online information:CC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Widely expressed in different hematopoietic cells.,

细胞定位：
Cell membrane ; Multi-pass membrane protein .

组织表达：
Widely expressed in different hematopoietic cells.

The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-κB/CCL3/CCR1 axis IHC Mouse Liver /
货号：YT5941