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Flt-4 Polyclonal Antibody

货号：YT5878
应用：WB;IHC;IF;ELISA
种属：Human;Mouse;Rat

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靶点：
VEGFR3

简介：
>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>PI3K-Akt signaling pathway;>>Focal adhesion;>>Pathways in cancer;>>Breast cancer

基因名称：
FLT4 VEGFR3

蛋白名称：
Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)

Human Gene Id：
2324

Human Swiss Prot No：
P35916

Mouse Gene Id：
14257

Mouse Swiss Prot No：
P35917

Rat Swiss Prot No：
Q91ZT1

免疫原：
Synthetic peptide from human protein at AA range: 640-700

特异性：
The antibody detects endogenous Flt-4

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500-2000,IHC 1:500-200, ELISA 1:10000-20000. IF 1:50-200

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
Vascular endothelial growth factor receptor 3 (VEGFR-3;EC 2.7.10.1;Fms-like tyrosine kinase 4;FLT-4;Tyrosine-protein kinase receptor FLT4)

实测条带：
170kD

背景：
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008],

功能：
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue.,disease:Defects in FLT4 are the cause of lymphedema hereditary type 1 (LYH1A) [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment.,function:Receptor for VEGFC. Has a tyrosine-protein kinas

细胞定位：
Cell membrane ; Single-pass type I membrane protein. Cytoplasm . Nucleus . Ligand-mediated autophosphorylation leads to rapid internalization. .; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Ligand-mediated autophosphorylation leads to rapid internalization.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted. Cytoplasm.

组织表达：
Detected in endothelial cells (at protein level). Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney.

Eplerenone inhibits UUO-induced lymphangiogenesis and cardiac fibrosis by attenuating inflammatory injury. INTERNATIONAL IMMUNOPHARMACOLOGYInt Immunopharmacol. 2022 Jul;108:108759. Rat 1:100,1:100 heart tissues
货号：YT5878

Exosomes derived from human umbilical cord mesenchymal stem cells regulate lymphangiogenesis via the miR-302d-3p/VEGFR3/AKT axis to ameliorate inflammatory bowel disease INTERNATIONAL IMMUNOPHARMACOLOGY Wei Qiu WB,IF Mouse
货号：YT5878

Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats Scientific Reports Hao Juan IHC,WB Rat,Mouse kidney tissue
货号：YT5878