• 靶点：
• IRS2

• 简介：
• >>cGMP-PKG signaling pathway;>>FoxO signaling pathway;>>Autophagy - animal;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Insulin signaling pathway;>>Adipocytokine signaling pathway;>>Regulation of lipolysis in adipocytes;>>Type II diabetes mellitus;>>Insulin resistance;>>Non-alcoholic fatty liver disease;>>Growth hormone synthesis, secretion and action;>>Alzheimer disease;>>MicroRNAs in cancer

• 基因名称：
• IRS2

• 蛋白名称：
• insulin receptor substrate 2

• Human Gene Id：
• 8660

• Human Swiss Prot No：
• Q9Y4H2

• Mouse Gene Id：
• 384783

• Mouse Swiss Prot No：
• P81122

• 免疫原：
• Synthetic peptide from human protein at AA range: 660-700

• 特异性：
• The antibody detects endogenous IRS2 protein

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000, ELISA 1:10000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• IRS2

• 实测条带：
• 170kD

• 背景：
• This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008],

• 功能：
• function:May mediate the control of various cellular processes by insulin.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,

• 细胞定位：
• Cytoplasm, cytosol .

• 组织表达：
• Blood,Epithelium,Platelet,

Tao, Hong, et al. "MiR-126 suppresses the glucose-stimulated proliferation via IRS-2 in INS-1 β cells." PloS one 11.2 (2016): e0149954.
货号：YT5836

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