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Synuclein-α Polyclonal Antibody

货号：YT5731
应用：WB;IHC;IF;ELISA
种属：Human;Mouse;Rat

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靶点：
Synuclein-α

简介：
>>Alzheimer disease;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases

基因名称：
SNCA

蛋白名称：
Alpha-synuclein

Human Gene Id：
6622

Human Swiss Prot No：
P37840

Mouse Gene Id：
20617

Mouse Swiss Prot No：
O55042

Rat Gene Id：
29219

Rat Swiss Prot No：
P37377

免疫原：
The antiserum was produced against synthesized peptide derived from the Internal region of human SNCA. AA range:21-70

特异性：
Synuclein-α Polyclonal Antibody detects endogenous levels of Synuclein-α protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500-2000;IHC 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
SNCA;NACP;PARK1;Alpha-synuclein;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;NACP

实测条带：
15kD

背景：
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016],

功能：
alternative products:Additional isoforms seem to exist,disease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCA is found in LB-like inclusions, glial inclusions and spheroids.,disease:Defects in SNCA are a cause of autosomal dominant Parkinson disease 1 (PARK1) [MIM:168601, 168600]. Parkinson disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early-onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages an

细胞定位：
Cytoplasm . Membrane . Nucleus . Cell junction, synapse . Secreted . Cell projection, axon . Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity). .

组织表达：
Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain.

Identification of miRNA-7 as a regulator of brain-derived neurotrophic factor/α-synuclein axis in atrazine-induced Parkinson’s disease by peripheral blood and brain microRNA profiling. CHEMOSPHERE 2019 May 23 WB Rat 1:1000 blood,brain tissue
货号：YT5731

Protective effects of saponins from Panax japonicus on neurons of the colon myenteric plexus in aging rats through reduction of α‐synuclein through endoplasmic reticulum stress. Geriatrics & Gerontology International 2020 Nov 27 IHC,IF Rat 1:400,1:400 Colon Enteric neurons
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Autophagy and UPS pathway contribute to nicotine-induced protection effect in Parkinson’s disease EXPERIMENTAL BRAIN RESEARCH Ullah Inam WB Caenorhabditis elegans 1:1500 body
货号：YT5731