• 靶点：
• IL-1F5

• 简介：
• >>Cytokine-cytokine receptor interaction

• 基因名称：
• IL36RN

• 蛋白名称：
• Interleukin-36 receptor antagonist protein

• Human Gene Id：
• 26525

• Human Swiss Prot No：
• Q9UBH0

• Mouse Gene Id：
• 54450

• Mouse Swiss Prot No：
• Q9QYY1

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human IL36RN. AA range:1-50

• 特异性：
• IL-1F5 Polyclonal Antibody detects endogenous levels of IL-1F5 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• IL36RN;FIL1D;IL1F5;IL1HY1;IL1L1;IL1RP3;Interleukin-36 receptor antagonist protein;FIL1 delta;IL-1-related protein 3;IL-1RP3;Interleukin-1 HY1;IL-1HY1;Interleukin-1 delta;IL-1 delta;Interleukin-1 family member 5;IL-1F5;Interleukin-1 receptor antagonist homolog 1;IL-1ra homolog 1;Interleukin-1-like protein 1;IL-1L1

• 实测条带：
• 17kD

• 背景：
• The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008],

• 功能：
• function:Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.,induction:By phorbol ester (PMA) and lipopolysaccharide (LPS) treatment in macrophage cell line.,online information:Interleukin-1 entry,similarity:Belongs to the IL-1 family.,tissue specificity:Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.,

• 细胞定位：
• Cytoplasm . Secreted . The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. .

• 组织表达：
• Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.

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