• 靶点：
• GDF-6

• 简介：
• >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Hippo signaling pathway

• 基因名称：
• GDF6

• 蛋白名称：
• Growth/differentiation factor 6

• Human Gene Id：
• 392255

• Human Swiss Prot No：
• Q6KF10

• Mouse Gene Id：
• 242316

• Mouse Swiss Prot No：
• P43028

• Rat Gene Id：
• 252834

• Rat Swiss Prot No：
• Q6HA10

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human GDF6. AA range:311-360

• 特异性：
• GDF-6 Polyclonal Antibody detects endogenous levels of GDF-6 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GDF6;GDF16;Growth/differentiation factor 6;GDF-6;Growth/differentiation factor 16

• 实测条带：
• 50kD

• 背景：
• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene are associated with Klippel-Feil syndrome, microphthalmia, and Leber congenital amaurosis. [provided by RefSeq, Sep 2016],

• 功能：
• disease:A chromosomal aberration involving GDF6 is associated with Klippel-Feil syndrome (KFS) [MIM:118100]. Paracentric inv(8)(q22;2q23.3).,disease:Defects in GDF6 are associated with Klippel-Feil syndrome (KFS) [MIM:118100]. Klippel-Feil syndrome is a complex skeletal disorder characterized by congenital fusion of vertebrae within the anterior/cervical spine. Vertebral fusion appears to be caused by a failure in the normal segmentation of vertebrae during the early weeks of fetal development and defective somitogenesis has been postulated as a mitigating factor. However, the etiology of KFS is still unknown and no definitive disease-causing genes have yet been identified. Although most cases are sporadic, both autosomal dominant and autosomal recessive inheritance have been reported.,function:Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Pla

• 细胞定位：
• Secreted .

• 组织表达：
• Hindbrain,Testis,

miR-98 is involved in missed abortion by targeting GDF6 and FAPP2. REPRODUCTION Reproduction. 2020 May;159(5):525-537 WB,IHC Human 1:100,1:250 Placental villi tissues， normal tissue HTR8/SVneo cell
货号：YT5653

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