Lambda 5 Polyclonal Antibody
- 货号：YT5641
- 应用：WB;IHC;IF;ELISA
- 种属：Human;Mouse
- 简介：
- >>Primary immunodeficiency
- 蛋白名称：
- Immunoglobulin lambda-like polypeptide 1
- 免疫原：
- The antiserum was produced against synthesized peptide derived from the C-terminal region of human IGLL1. AA range:151-200
- 特异性：
- Lambda 5 Polyclonal Antibody detects endogenous levels of Lambda 5 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- IGLL1;IGL1;Immunoglobulin lambda-like polypeptide 1;CD179 antigen-like family member B;Ig lambda-5;Immunoglobulin omega polypeptide;Immunoglobulin-related protein 14.1;CD179b
- 背景：
- immunoglobulin lambda like polypeptide 1(IGLL1) Homo sapiens The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
- 功能：
- disease:Defects in IGLL1 are a cause of autosomal recessive non-Bruton type agammaglobulinemia [MIM:601495]. It is characterized by agammaglobulinemia and markedly reduced numbers of B cells.,online information:IGLL1 mutation db,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Associates non-covalently with VPREB1.,tissue specificity:Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative).,
- 细胞定位：
- Endoplasmic reticulum . Secreted . In pre-B cells, localizes predominantly to the endoplasmic reticulum. .
- 组织表达：
- Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative).
- Western Blot analysis of KB cells using Lambda 5 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
