• 靶点：
• CD249

• 简介：
• >>Renin-angiotensin system

• 基因名称：
• ENPEP

• 蛋白名称：
• Glutamyl aminopeptidase

• Human Gene Id：
• 2028

• Human Swiss Prot No：
• Q07075

• Mouse Gene Id：
• 13809

• Mouse Swiss Prot No：
• P16406

• Rat Gene Id：
• 64017

• Rat Swiss Prot No：
• P50123

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human ENPEP. AA range:671-720

• 特异性：
• CD249 Polyclonal Antibody detects endogenous levels of CD249 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ENPEP;Glutamyl aminopeptidase;EAP;Aminopeptidase A;AP-A;Differentiation antigen gp160;CD249

• 实测条带：
• 110kD

• 背景：
• catalytic activity:Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.,cofactor:Binds 1 zinc ion per subunit.,function:Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.,similarity:Belongs to the peptidase M1 family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.,

• 功能：
• catalytic activity:Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.,cofactor:Binds 1 zinc ion per subunit.,function:Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.,similarity:Belongs to the peptidase M1 family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.,

• 细胞定位：
• Cell membrane ; Single-pass type II membrane protein.

• 组织表达：
• Expressed in choriocarcinoma cancer cell lines (at protein level) (PubMed:10692253). Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.

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