CD192 Polyclonal Antibody

    • 货号:YT5635
    • 应用:WB;ELISA
    • 种属:Human;Rat;Mouse;
      • 靶点:
      • CD192
      • 简介:
      • >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway
      • 基因名称:
      • CCR2
      • 蛋白名称:
      • C-C chemokine receptor type 2
      • Human Swiss Prot No:
      • P41597
      • Mouse Swiss Prot No:
      • P51683
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from the N-terminal region of human CCR2. AA range:1-50
      • 特异性:
      • CD192 Polyclonal Antibody detects endogenous levels of CD192 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • CCR2;CMKBR2;C-C chemokine receptor type 2;C-C CKR-2;CC-CKR-2;CCR-2;CCR2;Monocyte chemoattractant protein 1 receptor;MCP-1-R;CD192
      • 实测条带:
      • 42kD
      • 背景:
      • This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009],
      • 功能:
      • function:Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.,online information:CC chemokine receptors entry,polymorphism:Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423].,PTM:N-glycosylated.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Binds to HIV-1 Tat.,
      • 细胞定位:
      • Cell membrane ; Multi-pass membrane protein . The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. .
      • 组织表达:
      • Expressed by monocytes and IL2-activated NK cells.

      C-C Motif Chemokine 8 promotes angiogenesis in vascular endothelial cells:. Vascular 2020 Sep 25 WB Human HUVECs
      货号:YT5635

      • 产品图片
      • Western Blot analysis of NIH-3T3 cells using CD192 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
      • Western Blot analysis of 3T3 cells using CD192 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000