SAMHD1 Polyclonal Antibody

    • 货号:YT5491
    • 应用:WB;IHC;IF;ELISA
    • 种属:Human;Rat;Mouse;
      • 靶点:
      • SAMHD1
      • 简介:
      • >>Viral life cycle - HIV-1;>>Human immunodeficiency virus 1 infection
      • 基因名称:
      • SAMHD1
      • 蛋白名称:
      • SAM domain and HD domain-containing protein 1
      • Human Swiss Prot No:
      • Q9Y3Z3
      • Mouse Swiss Prot No:
      • Q60710
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from the Internal region of human SAMHD1. AA range:431-480
      • 特异性:
      • SAMHD1 Polyclonal Antibody detects endogenous levels of SAMHD1 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • SAMHD1;MOP5;SAM domain and HD domain-containing protein 1;Dendritic cell-derived IFNG-induced protein;DCIP;Monocyte protein 5;MOP-5
      • 实测条带:
      • 72kD
      • 背景:
      • SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1(SAMHD1) Homo sapiens This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010],
      • 功能:
      • function:May play a role in mediating proinflammatory responses to TNF-alpha signaling.,induction:By interferon gamma. Up-regulated in TNF-alpha treated lung fibroblasts.,similarity:Contains 1 HD domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,tissue specificity:Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus.,
      • 细胞定位:
      • Nucleus . Chromosome . Localizes to sites of DNA double-strand breaks in response to DNA damage. .
      • 组织表达:
      • Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes (PubMed:11064105). No expression is seen in brain and thymus (PubMed:11064105).
      • 产品图片
      • Western Blot analysis of PC12 cells using SAMHD1 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
      • Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:100
      • Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100