• 靶点：
• SAMHD1

• 简介：
• >>Viral life cycle - HIV-1;>>Human immunodeficiency virus 1 infection

• 基因名称：
• SAMHD1

• 蛋白名称：
• SAM domain and HD domain-containing protein 1

• Human Gene Id：
• 25939

• Human Swiss Prot No：
• Q9Y3Z3

• Mouse Gene Id：
• 56045

• Mouse Swiss Prot No：
• Q60710

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human SAMHD1. AA range:431-480

• 特异性：
• SAMHD1 Polyclonal Antibody detects endogenous levels of SAMHD1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SAMHD1;MOP5;SAM domain and HD domain-containing protein 1;Dendritic cell-derived IFNG-induced protein;DCIP;Monocyte protein 5;MOP-5

• 实测条带：
• 72kD

• 背景：
• SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1(SAMHD1) Homo sapiens This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010],

• 功能：
• function:May play a role in mediating proinflammatory responses to TNF-alpha signaling.,induction:By interferon gamma. Up-regulated in TNF-alpha treated lung fibroblasts.,similarity:Contains 1 HD domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,tissue specificity:Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus.,

• 细胞定位：
• Nucleus . Chromosome . Localizes to sites of DNA double-strand breaks in response to DNA damage. .

• 组织表达：
• Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes (PubMed:11064105). No expression is seen in brain and thymus (PubMed:11064105).

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