• 靶点：
• MPO

• 简介：
• >>Drug metabolism - other enzymes;>>Phagosome;>>Neutrophil extracellular trap formation;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia

• 基因名称：
• MPO

• 蛋白名称：
• Myeloperoxidase

• Human Gene Id：
• 4353

• Human Swiss Prot No：
• P05164

• Mouse Gene Id：
• 17523

• Mouse Swiss Prot No：
• P11247

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the N-terminal region of human MPO. AA range:41-90

• 特异性：
• MPO Polyclonal Antibody detects endogenous levels of MPO protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC: 100-300.WB 1:500 - 1:2000. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MPO;Myeloperoxidase;MPO

• 实测条带：
• 85kD

• 背景：
• Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014],

• 功能：
• catalytic activity:Cl(-) + H(2)O(2) = HOCl + 2 H(2)O.,catalytic activity:Donor + H(2)O(2) = oxidized donor + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,disease:Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.,function:Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.,online information:MPO mutation db,online information:Myeloperoxidase entry,similarity:Belongs to the peroxidase family. XPO sub

• 细胞定位：
• Lysosome.

• 组织表达：
• Leukemia,Leukocyte,Liver,Plasma,Saliva,

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