• 靶点：
• Integrin α4

• 简介：
• >>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Cell adhesion molecules;>>Hematopoietic cell lineage;>>Leukocyte transendothelial migration;>>Intestinal immune network for IgA production;>>Regulation of actin cytoskeleton;>>Yersinia infection;>>Leishmaniasis;>>Human papillomavirus infection;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy

• 基因名称：
• ITGA4

• 蛋白名称：
• Integrin alpha-4

• Human Gene Id：
• 3676

• Human Swiss Prot No：
• P13612

• Mouse Gene Id：
• 16401

• Mouse Swiss Prot No：
• Q00651

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human ITGA4. AA range:571-620

• 特异性：
• Integrin α4 Polyclonal Antibody detects endogenous levels of Integrin α4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ITGA4;CD49D;Integrin alpha-4;CD49 antigen-like family member D;Integrin alpha-IV;VLA-4 subunit alpha;CD49d

• 实测条带：
• 120kD

• 背景：
• integrin subunit alpha 4(ITGA4) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],

• 功能：
• domain:The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.,function:Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.,PTM:Phosphorylation on Ser-1027 inhibits PXN binding.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit

• 细胞定位：
• Membrane; Single-pass type I membrane protein.

• 组织表达：
• Lymph,Peripheral blood,Prostate,Spleen,Testis,

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