• 靶点：
• CD32

• 简介：
• >>Phagosome;>>Osteoclast differentiation;>>B cell receptor signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Staphylococcus aureus infection;>>Tuberculosis;>>Measles

• 基因名称：
• FCGR2B/FCGR2C

• 蛋白名称：
• Low affinity immunoglobulin gamma Fc region receptor II-b/Low affinity immunoglobulin gamma Fc region receptor II-c

• Human Gene Id：
• 2213

• Human Swiss Prot No：
• P31994

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human FCGR2B/C. AA range:141-190

• 特异性：
• CD32-B/C Polyclonal Antibody detects endogenous levels of CD32-B/C protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• FCGR2B;CD32;FCG2;IGFR2;Low affinity immunoglobulin gamma Fc region receptor II-b;IgG Fc receptor II-b;CDw32;Fc-gamma RII-b;Fc-gamma-RIIb;FcRII-b;CD32;FCGR2C;CD32;FCG2;IGFR2;Low affinity immunoglobulin gamma Fc region receptor II-c;IgG Fc receptor II-c;CDw32;Fc-gamma RII-c;Fc-gamma-RIIc;FcRII-c;CD32

• 实测条带：
• 35kD

• 背景：
• Low affinity immunoglobulin gamma Fc region receptor II-b/Low affinity immunoglobulin gamma Fc region receptor II-c encoded by FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.

• 功能：
• immune response,

• 细胞定位：
• Cell membrane; Single-pass type I membrane protein.

• 组织表达：
• Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

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