• 靶点：
• CUL4B

• 简介：
• >>Nucleotide excision repair;>>Ubiquitin mediated proteolysis;>>Human immunodeficiency virus 1 infection

• 基因名称：
• CUL4B

• 蛋白名称：
• Cullin-4B

• Human Gene Id：
• 8450

• Human Swiss Prot No：
• Q13620

• Mouse Gene Id：
• 72584

• Mouse Swiss Prot No：
• A2A432

• 免疫原：
• The antiserum was produced against synthesized peptide derived from the Internal region of human CUL4B. AA range:711-760

• 特异性：
• CUL-4B Polyclonal Antibody detects endogenous levels of CUL-4B protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CUL4B;KIAA0695;Cullin-4B;CUL-4B

• 实测条带：
• 110kD

• 背景：
• This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in CUL4B are the cause of Cabezas X-linked mental retardation syndrome (MRXC) [MIM:300354]; also called X-linked mental retardation with short stature small testes muscle wasting and tremor. MRXC patients show delayed puberty, hypogonadism, relative macrocephaly, moderate short stature, central obesity, unprovoked aggressive outbursts, fine intention tremor, pes cavus, and abnormalities of the toes.,disease:Defects in CUL4B are the cause of X-linked mental retardation-hypotonic facies syndrome type 2 (MRXHF2) [MIM:300639]; also called Smith-Fineman-Myers syndrome type 2 or SFM2. The distinguishing manifestations of MRXHF2 are relative microcephaly, short stature, hypertelorism, macrostomia, patulous lips, difficulty in speech, micrognathia, short thumbs and little fingers with adduction, hypotonia at age less than 10 years, and later hypertonia, restlessness, and seizures

• 细胞定位：
• Nucleus .

• 组织表达：
• Brain,Fetal liver,Testis,

Wen, Xu-Peng, et al. "Identification of Different Proteins Binding to Na, K-ATPase α1 in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome Cell Model by Proteomic Analysis." (2021).
货号：YT5188

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis WB Human 1:1000 /A549 cells
货号：YT5188

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