GABAA Rε Polyclonal Antibody
- 货号：YT5068
- 应用：WB;ELISA
- 种属：Human;Rat
- 简介：
- >>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>GABAergic synapse;>>Morphine addiction;>>Nicotine addiction
- 蛋白名称：
- Gamma-aminobutyric acid receptor subunit epsilon
- 免疫原：
- Synthesized peptide derived from the Internal region of human GABAA range: Rε.
- 特异性：
- GABAA Rε Polyclonal Antibody detects endogenous levels of GABAA Rε protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- GABRE;Gamma-aminobutyric acid receptor subunit epsilon;GABA(A) receptor subunit epsilon
- 背景：
- The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008],
- 功能：
- function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. Associates with alpha and beta subunits.,tissue specificity:Expressed in many tissues. Highest levels of expression in adult heart and placenta.,
- 细胞定位：
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
- 组织表达：
- Expressed in many tissues. Highest levels of expression in adult heart and placenta.
- Western Blot analysis of extracts from Jurkat cells, using GABAA Rε Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
