• 靶点：
• ENaC γ

• 简介：
• >>Taste transduction;>>Aldosterone-regulated sodium reabsorption

• 基因名称：
• SCNN1G

• 蛋白名称：
• Amiloride-sensitive sodium channel subunit gamma

• Human Gene Id：
• 6340

• Human Swiss Prot No：
• P51170

• Mouse Gene Id：
• 20278

• Mouse Swiss Prot No：
• Q9WU39

• Rat Gene Id：
• 24768

• Rat Swiss Prot No：
• P37091

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ENaC gamma. AA range:132-181

• 特异性：
• ENaC γ Polyclonal Antibody detects endogenous levels of ENaC γ protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SCNN1G;Amiloride-sensitive sodium channel subunit gamma;Epithelial Na(+) channel subunit gamma;ENaCG;Gamma-ENaC;Gamma-NaCH;Nonvoltage-gated sodium channel 1 subunit gamma;SCNEG

• 实测条带：
• 80kD

• 背景：
• Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009],

• 功能：
• disease:Defects in SCNN1G are a cause of Liddle syndrome [MIM:177200]. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.,function:Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.,PTM:Phosphorylated on serine and threonine residues.,PTM:Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.,similarity:Belongs to the amiloride-sensitive sodium channel family.,subcellular location:Apical me

• 细胞定位：
• Apical cell membrane ; Multi-pass membrane protein . Apical membrane of epithelial cells. .

• 组织表达：
• Expressed in kidney (at protein level).

Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury. Molecular Medicine Reports Mol Med Rep. 2021 Oct;24(4):1-13 IHC,WB Mouse 1:200,1:1000 Lung
货号：YT5032

Urea transporter UT-A1 as a novel drug target for hyponatremia FASEB JOURNAL Nannan Li WB Rat kidney tissue
货号：YT5032

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