• 靶点：
• ZIP1

• 简介：
• >>Alzheimer disease;>>Parkinson disease

• 基因名称：
• SLC39A1

• 蛋白名称：
• Zinc transporter ZIP1

• Human Gene Id：
• 27173

• Human Swiss Prot No：
• Q9NY26

• Mouse Swiss Prot No：
• Q9QZ03

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human SLC39A1. AA range:111-160

• 特异性：
• ZIP1 Polyclonal Antibody detects endogenous levels of ZIP1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SLC39A1;IRT1;ZIP1;ZIRTL;CGI-08;CGI-71;Zinc transporter ZIP1;Solute carrier family 39 member 1;Zinc-iron-regulated transporter-like;Zrt- and Irt-like protein 1;ZIP-1;hZIP1

• 实测条带：
• 38kD

• 背景：
• This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],

• 功能：
• function:Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.,miscellaneous:Inhibited by Ni(2+) ions. Fe(2+) ions do not inhibit zinc uptake.,similarity:Belongs to the ZIP transporter (TC 2.A.5) family.,subcellular location:Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.,tissue specificity:Ubiquitous. Expressed in most adult and fetal tissues including the epidermis.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.

• 组织表达：
• Ubiquitous. Expressed in most adult and fetal tissues including the epidermis.

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