• 靶点：
• XRCC3

• 简介：
• >>Homologous recombination

• 基因名称：
• XRCC3

• 蛋白名称：
• DNA repair protein XRCC3

• Human Gene Id：
• 7517

• Human Swiss Prot No：
• O43542

• Mouse Swiss Prot No：
• Q9CXE6

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human XRCC3. AA range:41-90

• 特异性：
• XRCC3 Polyclonal Antibody detects endogenous levels of XRCC3 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• XRCC3;DNA repair protein XRCC3;X-ray repair cross-complementing protein 3

• 实测条带：
• 38kD

• 背景：
• This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Met-241 is associated with the development of cutaneous malignant melanoma.,function:Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the recA family. RAD51 subfamily.,subunit:Interacts with RAD51C and RAD51. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3.,

• 细胞定位：
• Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.

• 组织表达：
• Cerebellum,Cervix carcinoma,Lymph,Muscle,Neuroblastoma,Placenta,

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