• 靶点：
• XRCC1

• 简介：
• >>Base excision repair

• 基因名称：
• XRCC1

• 蛋白名称：
• DNA repair protein XRCC1

• Human Gene Id：
• 7515

• Human Swiss Prot No：
• P18887

• Mouse Gene Id：
• 22594

• Mouse Swiss Prot No：
• Q60596

• Rat Gene Id：
• 84495

• Rat Swiss Prot No：
• Q9ESZ0

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human XRCC1. AA range:517-566

• 特异性：
• XRCC1 Polyclonal Antibody detects endogenous levels of XRCC1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• XRCC1;DNA repair protein XRCC1;X-ray repair cross-complementing protein 1

• 实测条带：
• 70kD

• 背景：
• The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],

• 功能：
• function:Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.,polymorphism:Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.,PTM:Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.,PTM:Sumoylated.,similarity:Contains 2 BRCT domains.,subcellular location:Accumulates at sites of DNA damage.,subunit:Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF.,

• 细胞定位：
• Nucleus . Moves from the nucleoli to the global nuclear chromatin upon DNA damage. .

• 组织表达：
• Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).

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