• 靶点：
• XIAP

• 简介：
• >>Platinum drug resistance;>>NF-kappa B signaling pathway;>>Ubiquitin mediated proteolysis;>>Apoptosis;>>Apoptosis - multiple species;>>Necroptosis;>>Focal adhesion;>>NOD-like receptor signaling pathway;>>Toxoplasmosis;>>Human T-cell leukemia virus 1 infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Small cell lung cancer

• 基因名称：
• XIAP

• 蛋白名称：
• E3 ubiquitin-protein ligase XIAP

• Human Gene Id：
• 331

• Human Swiss Prot No：
• P98170

• Mouse Gene Id：
• 11798

• Mouse Swiss Prot No：
• Q60989

• Rat Gene Id：
• 63879

• Rat Swiss Prot No：
• Q9R0I6

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human XIAP. AA range:53-102

• 特异性：
• XIAP Polyclonal Antibody detects endogenous levels of XIAP protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• XIAP;API3;BIRC4;IAP3;E3 ubiquitin-protein ligase XIAP;Baculoviral IAP repeat-containing protein 4;IAP-like protein;ILP;hILP;Inhibitor of apoptosis protein 3;IAP-3;hIAP-3;hIAP3;X-linked inhibitor of apoptosis protein;X-linked I

• 实测条带：
• 57kD

• 背景：
• This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011],

• 功能：
• disease:Defects in XIAP are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2) [MIM:300635]. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.,domain:The first BIR domain is involved in interaction with MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit caspase-3 and caspase-7, while the third BIR is involved in caspase-9 inhibition. The interactions with SMAC and PRSS25 are mediated by the second and third BIR domains.,function:Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, lead

• 细胞定位：
• Cytoplasm. Nucleus. TLE3 promotes its nuclear localization.

• 组织表达：
• Expressed in colonic crypts (at protein level) (PubMed:30389919). Ubiquitous, except peripheral blood leukocytes (PubMed:8654366).

Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 cells by regulating apoptotic and Nrf2/p62 pathways. FOOD AND CHEMICAL TOXICOLOGY Food Chem Toxicol. 2021 Nov;157:112582 WB Human 1:1000 HepG2 cell
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Quantitative proteomics and bioinformatics analyses reveal the protective effects of cyanidin-3-O-glucoside and its metabolite protocatechuic acid against 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-induced cytotoxicity in HepG2 cells via apoptosis-relat. FOOD AND CHEMICAL TOXICOLOGY Food Chem Toxicol. 2021 Jul;153:112256 WB Human 1:1000 HepG2 cell
货号：YT4913

Targeting FoxM1 by thiostrepton inhibits growth and induces apoptosis of laryngeal squamous cell carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 2014 Nov 13 WB Human Hep-2 cell
货号：YT4913

Down-regulation of FoxM1 by thiostrepton or small interfering RNA inhibits proliferation, transformation ability and angiogenesis, and induces apoptosis of nasopharyngeal carcinoma cells. International Journal of Clinical and Experimental Pathology Int J Clin Exp Patho. 2014; 7(9): 5450–5460 WB Human Nasopharyngeal carcinoma (NPC) cell
货号：YT4913

AP-1 confers resistance to anti-cancer therapy by activating XIAP. Oncotarget Oncotarget. 2018 Mar 6; 9(18): 14124–14137 WB Human MCF7 cell
货号：YT4913

Target Identification-Based Analysis of Mechanism of Betulinic Acid-Induced Cells Apoptosis of Cervical Cancer SiHa: Natural Product Communications Hao Sun WB Human
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