• 靶点：
• Wnt-1

• 简介：
• >>mTOR signaling pathway;>>Wnt signaling pathway;>>Hippo signaling pathway;>>Signaling pathways regulating pluripotency of stem cells;>>Melanogenesis;>>Cushing syndrome;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Human papillomavirus infection;>>Pathways in cancer;>>Proteoglycans in cancer;>>Chemical carcinogenesis - receptor activation;>>Basal cell carcinoma;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer

• 基因名称：
• WNT1

• 蛋白名称：
• Proto-oncogene Wnt-1

• Human Gene Id：
• 7471

• Human Swiss Prot No：
• P04628

• Mouse Gene Id：
• 22408

• Mouse Swiss Prot No：
• P04426

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human WNT1. AA range:301-350

• 特异性：
• Wnt-1 Polyclonal Antibody detects endogenous levels of Wnt-1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• WNT1;INT1;Proto-oncogene Wnt-1;Proto-oncogene Int-1 homolog

• 实测条带：
• 45kD

• 背景：
• The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in

• 功能：
• function:Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.,similarity:Belongs to the Wnt family.,subunit:Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3.,

• 细胞定位：
• Secreted, extracellular space, extracellular matrix . Secreted .

• 组织表达：
• Testis,

Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 2016 Dec 01 WB Human U2OS cell
货号：YT4907

Aerobic exercise training engages the canonical wnt pathway to improve pulmonary function and inflammation in COPD BMC Pulmonary Medicine Peijun Li WB Mouse 1:2000 lung tissue
货号：YT4907

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