• 靶点：
• VPAC2

• 简介：
• >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction

• 基因名称：
• VIPR2

• 蛋白名称：
• Vasoactive intestinal polypeptide receptor 2

• Human Gene Id：
• 7434

• Human Swiss Prot No：
• P41587

• Mouse Gene Id：
• 22355

• Mouse Swiss Prot No：
• P41588

• Rat Gene Id：
• 29555

• Rat Swiss Prot No：
• P35000

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human VIPR2. AA range:83-132

• 特异性：
• VPAC2 Polyclonal Antibody detects endogenous levels of VPAC2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• VIPR2;VIP2R;Vasoactive intestinal polypeptide receptor 2;VIP-R-2;Helodermin-preferring VIP receptor;Pituitary adenylate cyclase-activating polypeptide type III receptor;PACAP type III receptor;PACAP-R-3;PACAP-R3;VPAC2

• 实测条带：
• 49kD

• 背景：
• vasoactive intestinal peptide receptor 2(VIPR2) Homo sapiens This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011],

• 功能：
• function:This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, PEER, MOLT-4, HSB, YT and Tsup-1, but not in the T-cell lines HARRIS and HUT 78.,

• 细胞定位：
• Cell membrane; Multi-pass membrane protein.

• 组织表达：
• Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78.

Sympathetic Neurotransmitter, VIP, Delays Intervertebral Disc Degeneration via FGF18/FGFR2-Mediated Activation of Akt Signaling Pathway Advanced Biology Kaiqiang Sun IHC,IF Human nucleus pulposus (NP) tissue nucleus pulposus (NP) cell
货号：YT4888

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