• 靶点：
• VEGF-B

• 简介：
• >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>PI3K-Akt signaling pathway;>>Focal adhesion;>>Relaxin signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Pathways in cancer

• 基因名称：
• VEGFB

• 蛋白名称：
• Vascular endothelial growth factor B

• Human Gene Id：
• 7423

• Human Swiss Prot No：
• P49765

• Mouse Gene Id：
• 22340

• Mouse Swiss Prot No：
• P49766

• Rat Gene Id：
• 89811

• Rat Swiss Prot No：
• O35485

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human VEGFB. AA range:91-140

• 特异性：
• VEGF-B Polyclonal Antibody detects endogenous levels of VEGF-B protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• VEGFB;VRF;Vascular endothelial growth factor B;VEGF-B;VEGF-related factor;VRF

• 实测条带：
• 21kD

• 背景：
• This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011],

• 功能：
• alternative products:Additional isoforms seem to exist,function:Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.,PTM:VEGF-B186 is O-glycosylated.,similarity:Belongs to the PDGF/VEGF growth factor family.,subcellular location:Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.,subunit:Homodimer; disulfide-linked. Can also form heterodimer with VEGF.,tissue specificity:Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.,

• 细胞定位：
• Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

• 组织表达：
• Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.

SALL4 promotes angiogenesis in gastric cancer by regulating VEGF expression and targeting SALL4/VEGF pathway inhibits cancer progression. Xu Zhang WB Human MKN-45 cell, MGC-803 cell, HGC-27 cell
货号：YT4871

Hemodynamic force dictates endothelial angiogenesis through MIEN1-ERK/MAPK-signaling axis JOURNAL OF CELLULAR PHYSIOLOGY Lin Cheng WB,IF Human Human umbilical vein endothelial cells (HUVECs)
货号：YT4871

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