• 靶点：
• UBE2D2

• 简介：
• >>Ubiquitin mediated proteolysis;>>Protein processing in endoplasmic reticulum;>>Shigellosis

• 基因名称：
• UBE2D2

• 蛋白名称：
• Ubiquitin-conjugating enzyme E2 D2

• Human Gene Id：
• 7322

• Human Swiss Prot No：
• P62837

• Mouse Gene Id：
• 56550

• Mouse Swiss Prot No：
• P62838

• Rat Gene Id：
• 641452

• Rat Swiss Prot No：
• P62839

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human UBE2D2. AA range:98-147

• 特异性：
• UBE2D2 Polyclonal Antibody detects endogenous levels of UBE2D2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• UBE2D2;UBC4;UBC5B;UBCH4;UBCH5B;Ubiquitin-conjugating enzyme E2 D2;Ubiquitin carrier protein D2;Ubiquitin-conjugating enzyme E2(17)KB 2;Ubiquitin-conjugating enzyme E2-17 kDa 2;Ubiquitin-protein ligase D2

• 实测条带：
• 17kD

• 背景：
• Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013],

• 功能：
• catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex and with E3 ubiquitin-protein ligase PJA2.,

• 细胞定位：
• ubiquitin ligase complex,nucleoplasm,cytosol,protein complex,extracellular exosome,

• 组织表达：
• Brain,Cajal-Retzius cell,Testis,

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