• 靶点：
• TRP2

• 简介：
• >>Tyrosine metabolism;>>Metabolic pathways;>>Melanogenesis

• 基因名称：
• DCT

• 蛋白名称：
• L-dopachrome tautomerase

• Human Gene Id：
• 1638

• Human Swiss Prot No：
• P40126

• Mouse Gene Id：
• 13190

• Mouse Swiss Prot No：
• P29812

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human DCT. AA range:51-100

• 特异性：
• TRP2 Polyclonal Antibody detects endogenous levels of TRP2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• DCT;TYRP2;L-dopachrome tautomerase;DCT;DT;L-dopachrome Delta-isomerase;Tyrosinase-related protein 2;TRP-2;TRP2

• 实测条带：
• 60kD

• 背景：
• catalytic activity:L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.,cofactor:Binds 2 zinc ions per subunit.,function:Involved in regulating eumelanin and phaeomelanin levels.,pathway:Pigment biosynthesis; melanin biosynthesis.,similarity:Belongs to the tyrosinase family.,subunit:Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.,

• 功能：
• catalytic activity:L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.,cofactor:Binds 2 zinc ions per subunit.,function:Involved in regulating eumelanin and phaeomelanin levels.,pathway:Pigment biosynthesis; melanin biosynthesis.,similarity:Belongs to the tyrosinase family.,subunit:Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.,

• 细胞定位：
• Melanosome membrane ; Single-pass type I membrane protein . Melanosome . Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. .

• 组织表达：
• Liver,Lymphnode melanoma metastases,Mammary gland,Melanoma,

Flower extracts from Paeonia decomposita and Paeonia ostii inhibit melanin synthesis via cAMP‐CREB‐associated melanogenesis signaling pathways in murine B16 melanoma cells. JOURNAL OF FOOD BIOCHEMISTRY 2019 Jan 24 WB Mouse 1:3000–5000 B16 melanoma cell
货号：YT4750

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