• 靶点：
• TRADD

• 简介：
• >>MAPK signaling pathway;>>NF-kappa B signaling pathway;>>Sphingolipid signaling pathway;>>Apoptosis;>>Necroptosis;>>RIG-I-like receptor signaling pathway;>>IL-17 signaling pathway;>>TNF signaling pathway;>>Adipocytokine signaling pathway;>>Alcoholic liver disease;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection;>>Tuberculosis;>>Hepatitis C;>>Measles;>>Human cytomegalovirus infection;>>Influenza A;>>Human papillomavirus infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Human immunodeficiency virus 1 infection;>>Viral carcinogenesis

• 基因名称：
• TRADD

• 蛋白名称：
• Tumor necrosis factor receptor type 1-associated DEATH domain protein

• Human Gene Id：
• 8717

• Human Swiss Prot No：
• Q15628

• Mouse Gene Id：
• 71609

• Mouse Swiss Prot No：
• Q3U0V2

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human TRADD. AA range:251-300

• 特异性：
• TRADD Polyclonal Antibody detects endogenous levels of TRADD protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TRADD;Tumor necrosis factor receptor type 1-associated DEATH domain protein;TNFR1-associated DEATH domain protein;TNFRSF1A-associated via death domain

• 实测条带：
• 34kD

• 背景：
• The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008],

• 功能：
• domain:Requires the intact DEATH domain to associate with TNFRSF1A/TNFR1.,function:Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.,similarity:Contains 1 death domain.,subunit:Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP.,tissue specificity:Found in all examined tissues.,

• 细胞定位：
• Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Shuttles between the cytoplasm and the nucleus. .

• 组织表达：
• Found in all examined tissues.

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