• 靶点：
• TPH2

• 简介：
• >>Tryptophan metabolism;>>Folate biosynthesis;>>Metabolic pathways;>>Serotonergic synapse

• 基因名称：
• TPH2

• 蛋白名称：
• Tryptophan 5-hydroxylase 2

• Human Gene Id：
• 121278

• Human Swiss Prot No：
• Q8IWU9

• Mouse Gene Id：
• 216343

• Mouse Swiss Prot No：
• Q8CGV2

• Rat Gene Id：
• 317675

• Rat Swiss Prot No：
• Q8CGU9

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human TPH2. AA range:4-53

• 特异性：
• TPH2 Polyclonal Antibody detects endogenous levels of TPH2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TPH2;NTPH;Tryptophan 5-hydroxylase 2;Neuronal tryptophan hydroxylase;Tryptophan 5-monooxygenase 2

• 实测条带：
• 56kD

• 背景：
• This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016],

• 功能：
• catalytic activity:L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,disease:Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].,pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,similarity:Contains 1 ACT domain.,tissue specificity:Brain specific.,

• 细胞定位：
• cytosol,neuron projection,

• 组织表达：
• Brain specific.

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