• 靶点：
• Tryptophan Hydroxylase

• 简介：
• >>Tryptophan metabolism;>>Folate biosynthesis;>>Metabolic pathways;>>Serotonergic synapse

• 基因名称：
• TPH1

• 蛋白名称：
• Tryptophan 5-hydroxylase 1

• Human Gene Id：
• 7166

• Human Swiss Prot No：
• P17752

• Mouse Gene Id：
• 21990

• Mouse Swiss Prot No：
• P17532

• Rat Gene Id：
• 24848

• Rat Swiss Prot No：
• P09810

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Tryptophan Hydroxylase. AA range:231-280

• 特异性：
• TPH1 Polyclonal Antibody detects endogenous levels of TPH1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TPH1;TPH;TPRH;TRPH;Tryptophan 5-hydroxylase 1;Tryptophan 5-monooxygenase 1

• 实测条带：
• 51kD

• 背景：
• This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009],

• 功能：
• catalytic activity:L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,similarity:Contains 1 ACT domain.,subunit:Multimer of identical subunits.,tissue specificity:Isoform 2 seems to be less widely expressed than isoform 1.,

• 细胞定位：
• cytosol,neuron projection,

• 组织表达：
• [Isoform 2]: Seems to be less widely expressed than isoform 1.

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